The year is 2039. America has become multicultural in the truest sense, and a hodgepodge of languages can be heard anywhere you go. Advances in communications make it possible to view any major city in the world from any computer or television. Transportation is powered entirely by electricity, and power plants for cities and homes are autonomous. America is no longer dependent on fossil fuels, and the country enjoys a time of prosperity.

The year is 2040. On February 23, a virus is released from a lab in New Jersey and quickly goes airborne. Dubbed "the Mange Virus", it turns all those who become infected into raving beasts with no memory of their former selves. 98% of the population becomes Infected, but 1.8% are immune to the Mange Virus. However, this small percentage is not enough to stem the tide of the Infected. Millions die, and millions more are lost to the Virus.

The year is 2040. On March 1st, the government takes action to protect the people from the virus, delivering food and necessities to communities across the nation. Blood samples are taken from the Immunes in hopes of synthesizing a cure. But no such cure is produced, and provision deliveries to the suburbs slow, then stop altogether. Provisions are still delivered to the cities to keep up appearances to the rest of the world, while the remnants of government retreat to their labs in the country. The few still alive are left to fend for themselves.

The year is 2050. Many Immunes have died, but the survivors have formed small strongholds outside of the cities. Large cities have become dens for the Infected, and they are rarely seen in the suburbs where the Immunes reside. Life for Immunes attains a semblance of normalcy--until, during a run into Chicago for supplies, another community is discovered: the Carriers. Posessing some bestial traits of the Infected but retaining their human personalities, these Carriers may be the clue to creating the cure for the Mange Virus. But not all Immunes are willing to accept them so easily. Tensions run high as the humans deliberate whether to reveal the Carriers to the government that abandoned them... or to just let them die. And do the Carriers even want to be discovered?

A pack of Carriers at the heart of the city. An organization dedicated to wiping out Infected. A cult with a sinister purpose shrouded in mystery. A group of suburban Immunes just trying to get by. In this harsh new world built on the rubble of the old, there are no guarantees and there are no rules. When these groups clash, who will be left standing--and will anything human remain?